RESEARCH AND DEVELOPMENT

Chronic wounds are a major global health problem. 1-2% of the general population are affected, and the incidence is likely to increase due to the aging population and the rising prevalence of metabolic diseases. The market potential for wound care products is estimated at more than 18 billion $ in 2021.
There is a high medical need for novel and more efficient therapies for chronic, non-healing wounds.

We focus on a new systems-biology driven translational drug discovery approach for the therapy of chronic wounds. Our unique entry point takes advantage of the fact that the pathogenic drivers of wound chronicity are contained in patient material. Using patient samples we have established and patented novel assay systems which we use for compound screening, profiling and developing devices for personalized medicine.

Poster Presentations at International Meetings


Schoefmann N, Doerfler P, Berli M, Binder B, Botter SM, Hafner J, Hanfstingl K, Hoetzenecker W, Holzer JCJ, Kamolz LP, Mica L, Michelitsch B, Nischwitz S, Popovits M, Restivo G, Stuetz A, Wolff-Winiski B
Development of an ex vivo assay to differentiate between non-healing and healing wounds based on wound swabs.
Poster at the European Wound Management Association (EWMA), 18-20 November, 2020



Doerfler P, Schoefmann N, Stuetz A, Wolff-Winiski B
Screening of wound healing therapeutics with an ex vivo assay platform using wond exudates from individual patients.
Talk at the European Wound Management Association (EWMA), 18-20 November, 2020



Schoefmann N, Doerfler P, Stuetz A, Wolff-Winiski B
Identification of the Poly(ADP-Ribose) Polymerase (PARP) inhibitor Veliparib as potential new drug for chronic wound therapy.
Poster at the European Academy of Dermatology and Venereology (EADV), 28-31 October, 2020



Doerfler P, Schoefmann N, Berli M, Bauer W, Botter S, Frustaci D, Görge T, Luger T, Mica L, Popovits M, Rappersberger K, Stingl G, Stockinger T, Stütz A, Wolff-Winiski B
On the Way to Personalized Treatment of Chronic Wounds.
Poster at the European Academy of Dermatology and Venereology (EADV), 28-31 October, 2020



Popovits M, Aigner F, Schoefmann N, Doerfler P, Wolff-Winiski B
Einsatz von funktionellen Biomarkern in der Verlaufskontrolle von chronischen Wunden.
Poster at Österreichischer Chirurgenkongress, 17-18 October, 2020



Dörfler P, Bauer W, Görge T, Luger T, Rappersberger K, Stingl G, Schöfmann N, Stockinger T, Stütz A, Wolff-Winiski B
Effect of human wound exudates obtained by vacuum therapy on fibroblast proliferation and extracellular matrix formation.
29th Conference of the European Wound Management Association (EWMA), 5-7 June, 2019, Gothenborg, Sweden



Dörfler P, Stütz A, Wolff-Winiski B
Effect of exogenous platelet-derived growth factor on proliferation of human fibroblasts in the presence of human wound exudates
International Investigative Dermatology Meeting, 2018, Orlando, USA, 2018

J Invest Dermatol 138, Suppl 1:S242, Abstr. No 1428


Dörfler P, Bauer W, Görge T, Luger T, Rappersberger K, Stingl G, Stockinger T, Stütz A, Wolff-Winiski B
Comparative analysis of cytokines, proteases and growth factors in human wound exudates obtained by vacuum therapy
47th European Society Dermatological Research Meeting, Salzburg, Austria, 2017

J Invest Dermatol 137, Suppl 1:S312, Abstr. No 694